Many articles have been published describing the use and benefits of the Xcelodose® micro-dosing system. A selection of useful articles appear below. Additional articles appear in the Capsugel Library.

J. C. D. Sutch, I Shrubb and W. G. Cook. "A novel method to evaluate powder flow properties using small sample quantities". Journal of Pharmacy and Pharmacology 2007; Supplement 1.

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S. Bryant et. al., "Advances in Powder-Dosing Technology", Innov. in Pharm. Technol., June 2002

The Xcelodose system offers a "step change" in the way that early clinical trial supplies can be formulated - resulting in real savings in development times and costs.

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D. Mouro et.al., "Enhancement of Xcelodose Capsule-filling Capabilities Using Roller Compaction", Pharm. Technol., February 2006

The Xcelodose microfilling system is used to demonstrate that roller compaction followed by milling is a viable pre-processing technique for high dose chemical-in-capsule dosage forms. The process results in higher bulk and tapped densities for drug substances compared with milling alone.

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D. Edwards, "Accelerating Drug Development with Precision Dosing Techniques", Pharmaceutical Manufacturing and Packing Sourcer, Autumn 2004

Speeding up the development process (and thereby reaping the rewards) is seen as the 'Holy Grail' within the pharma industry. Xcelodose technology has been adopted by many of the leading global pharmaceutical companies to improve development timelines and speed up the go/no go decision-making process for drug development.

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Advertisement, "Particle Size: its importance in determining API release" Manufacturing Chemist, June 2005

Xcelodose, a unique microdosing system, sets new standards in powder dispensing and thereby facilitates 'Faster Time to First In Man'^™.

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I. Gill et. al., "Automating the Preparation of Test Articles and Clinical Trial Supplies", European Pharmaceutical Contractor, Winter 2001

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M. Hariharan, L. D. Ganorkar, G. E. Amidon, et al. Reducing the Time to Develop and Manufacture Formulations for First Oral Dose in Humans. Pharmaceutical Technology. October 2003

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