Discovering viable and profitable new drugs today often requires working with NCE's that are "poorly" water soluble. These NCE's can require time-consuming experimentation and analysis in order to achieve satisfactory drug absorption from a solid oral dosage form – a challenge that can some times take years of development without yielding positive results. However by formulating in lipid-based liquid or semi-solid formats, bioavailability can be significantly improved. API content uniformity can be improved as well, particularly at low dosage levels.

Re-formulating existing drugs in lipid-based liquid or semi-solid formats is also an excellent way to extend patent protection, extend the product life-cycle, or create an exciting new line extension for OTC drugs.

To assist customers in achieving these goals and help scientists exploit the potential of lipid-based formulations for poorly soluble compounds, Capsugel created the CFS 1200 Liquid Filling and Sealing machine. This bench-top machine helps accelerate the development time-frame and achieve 'Faster Time to First in Man.' A fully-automatic, cGMP compliant machine, it fills and seals up to 1,200 LicapsŪ capsules per hour with liquid or semi-solid formulations - all without banding.

Installation support and a comprehensive validation package is included with the sale of each CFS 1200 machine. Capsugel's highly experienced technical service team is also available to assist customers with hands-on support and to help optimize machine performance.

For customers wishing to contract out specific services or the entire development and manufacturing process, the staff at Capsugel's state-of-the-art Pharmaceutical Research and Development Center is ready to assist. Specializing in lipid-based formulations, Capsugel utilizes its LicapsŪ Drug Delivery System to help customers achieve their goals. Offering services from pre-clinical to commercial production, the center is remarkably flexible in terms of partnering with clients to match their exact needs.

To speak with a Capsugel representative in your area about liquid formulations or for Licaps product samples, click here.