Capsugel has successfully used a variety of formulation strategies, tailored to the needs of the specific drug or problem statement, to achieve colonic drug delivery, including:
One of the challenges to successful colonic delivery is the relatively small amount of water available for dissolution of dosage forms in the colon. The combination of reliable targeting technology and the delivery of drugs in a liquid dosage form can provide an optimal approach for colonic delivery.
We have successfully used these colonic-delivery formulations in liquid fill format for a number of development projects, progressing formulations into preclinical and clinical studies
Dr. Stephen Brown, CEO of Encap, explains how over 20 years of research and development, along with world-leading expertise in liquid-filled hard capsule delivery systems, has led to the commercial launch of ENCODE, a colon delivery technology platform for pharmaceutical development.