Pin & Hammer Milling

Capsugel’s unique combination of science and engineering expertise is core to our offering at each stage of a product’s development and manufacturing cycle. Working closely with clients from design onward, we can create optimized formulations with the greatest chances of therapeutic and commercial success.

Particle Size Engineering through Micronization

Stability, flowability, dissolution rate and bioavailability are all critical performance parameters affected by the size distribution of particles.  As part of our integrated product-development services, Capsugel offers premier particle-size reduction capability through micronization, pin milling, and hammer milling, as well as particle classification systems, for active pharmaceutical ingredients as well as functional excipients.  These particle engineering options include phase-appropriate equipment scaled to support early phase development studies through commercial manufacture.

 

Pin Milling

In pin milling, material is fed into a grinding chamber where a spinning disk with various size pins create a torturous flow path. Particles are fractured through direct impact or from shear forces against stator/fixed chamber surfaces, leading to size reduction. Pin design and the rotational speed of the disk can be varied to influence the size of the particles created.

Advantages of Pin Milling

  • Preferred and most economical choice when particle-size distributions of 100 to 400 microns are desired.
  • Ideal for declumping and creating free-flowing powders
  • Ideal for hard, difficult-to-grind materials such as resins used in pharmaceutical processing and polymeric excipients

Hammer Milling

In hammer milling, material is fed into a grinding chamber where a series of spinning blades impact particles, creating shear against fixed chamber surfaces and/or direct particle fracture reducing in particle size. The size of screen mesh at the mill outlet, rotational speed of blades and blade design can be varied to influence the size of the particles created.

Advantages

  • Preferred and most economical choice when distributions of several hundred microns are desired
  • Ideal for declumping and creating free-flowing powders
  • Ideal for hard, difficult-to-grind materials
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