Formulation & Processing of Amorphous Solid Dispersions for Poorly Soluble Drugs by Hot-Melt Extrusion

Hot-melt extrusion (HME) of amorphous solid dispersions offers an effective approach to formulate compounds with limited bioavailability due to low solubility and low dissolution rates. This webinar describes an integrated process and formulation approach that balances the target absorption profile, manufacturability, physical and chemical stability, and API availability to rapidly develop a progressable drug intermediate and dosage form for preclinical and clinical manufacture. The bioenhancement technology selection and HME process optimization processes are presented, as are representative case studies.