This technical article describes a novel ionic liquid technology that offers a new way to improve bioavailability lipid-based formulations and potentially reduce patients’ daily dose requirements. This technology is based on lipid-like counter-ion salts to improve the solubility of lipid-based liquid, semisolid, and multiparticulate formulations. These ionic liquids offer formulators the potential to reduce absorption variability, decrease excipient levels, and reduce bill burden.