AAPS 2015 Poster - Capsule Technology - T3167 - Capsule Selection Guidance: Bioequivalence or Enhancement of Vcaps® Plus Relative to Gelatin Capsules Based on Drug Properties

Vcaps® Plus, made from hydroxypropyl methylcellulose (HPMC), are an attractive alternative to gelatin capsules. They are plant-based, have improved crack resistance at low humidity, and are rapidly dissolving. Several studies have demonstrated that capsule composition can affect the bioavailability of drugs due to either disintegration rate or interactions between the drug and the capsule materials.