Data Integration Methodology that Leverages Coupled Bioreactor Monitoring Tools, Automated Sampling and Applied Mathematics to Redefine Bioreactor Operation

Optimization of bioreactor operation, media composition, and feed strategies typically involves a significant set of experiments based on limited, empirical, primarily off-line/at line, and few on-line data sets. Since cell physiology dynamically affects the nutrient requirements of the culture, it is critical to obtain the appropriate data over appropriate time intervals to assess the impact of process conditions on the cell population.

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