Spray-drying is a powerful formulation tool to enhance the bioavailability of compounds with low aqueous solubility. This webinar describes the fundamentals of spray-dried dispersion (SDD) formulations, including their solubilization performance, stability, and manufacturing. More than 1,000 spray-dried dispersion formulations have been successfully prepared at scales ranging from milligram quantities to metric tons. Process development, technology transfer, and scale-up are efficient due to use of a comprehensive set of experimental tools and fundamental models. The methodology results in low bulk-drug requirements for early-stage testing and rapid turnaround times to support fast-paced projects.