With an increasing number of low-solubility drugs emerging as new drug candidates, enabling technologies that improve aqueous solubility are in high demand. This webinar explores an attractive option with a proven track record in solubility enhancement: amorphous solid dispersions prepared by hot-melt extrusion (HME) technology. HME technology offers a number of advantages, including low capital and manufacturing costs, a small equipment footprint, and a continuous process scheme. This webinar reviews the requirements for HME formulations, compares HME products to amorphous dispersions produced by spray-drying, and provides an overview of the HME process, including equipment components and process variables.