Hot-Melt Extrusion of Amorphous Solid Dispersion for Bioavailability Enhancement

Amorphous solid dispersions made by hot-melt extrusion (HME) can be an effective tool in enhancing the bioavailability of BCS Class II compounds with low solubility. This webinar provides an overview of preparing amorphous dispersions using the HME process, covering formulation and process considerations. A process development flowchart is used to streamline formulation and process development, balancing the performance, manufacturability, and stability of HME formulations.