An increasing number of new drug entities require solubilization technologies for efficacious use. This webinar reviews the use of multicomponent amorphous dispersion systems, in which two or more excipients are formulated with the API for bioavailability enhancement of the low-solubility compound. The use of amorphous spray-dried dispersion formulations is highlighted, including an overview of the formulation process, the physical state of formulation components, and rapid performance screening tests that are used to guide selection of formulation components. In addition, the design of multicomponent amorphous formulations is described. Case studies are presented that show how multicomponent amorphous compositions and architectures can be used to simultaneously achieve manufacturability, physical stability, rapid dissolution, and sustainment of supersaturated drug concentrations.