Hypromellose is a common polymeric pharmaceutical excipient, and hypromellose capsules recently have been introduced for use in unit dose dry powder inhalation (DPI) devices. The present study demonstrated consistent and high performance of Capsugel® VCaps® hypromellose capsules, measured both by puncture uniformity and emitted dose of excipient from an Aerolizer device. Thus, this type of capsule appears well suited for use in future DPI products.