Performance of Hypromellose (Vcaps®) Capsules for Unit Dose Dry Powder Inhalation Devices

Respiratory Drug Delivery Europe 2009Hypromellose (hydroxypropyl methylcellulose) is a common polymeric pharmaceutical excipient, and hypromellose capsules recently have been introduced for use in unit dose dry powder inhalation (DPI) devices. The superior uniformity of capsule integrity (Stein 2007), lower baseline moisture content, and more stable hygroscopicity relative to gelatin capsules in varied relative humidity are a presumed advantage of hypromellose capsules (Nagata 2002, Birchall 2008). The stable moisture content should provide for more uniform puncture and consistent delivered dose in DPI devices.

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