Small-Scale Manufacture of Modified Release Coated Beads for Pre-clinical Drug Discovery Research

Drug Discovery Research using preclinical animals requires broadly applicable small scale formulation methods for assessing at an early stage compounds and targets. The present work focuses on manufacture and performance of small scale modified release formulations using a custom built “micro” fluid-bed system capable of spray-coating nominally 0.5 to 1-g batches (approximately 100 mg API) of 60 μm diameter particles.

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