Solid Nanocrystalline Dispersions of Ziprasidone with Enhanced Bioavailability in the Fasted State

Reducing the absorption difference between fed and fasted states is an important goal in the development of pharmaceutical dosage forms. The goal of this work was to develop and characterize a solid nanocrystalline dispersion (SNCD) to improve the oral absorption of ziprasidone in the fasted state, reducing the food effect observed for the commercial formulation. An SNCD was prepared from a spray-dried dispersion that was created from ziprasidone hydrochloride and hydroxypropyl methylcellulose acetate succinate (HPMCAS). Following characterization studies, in vivo pharmacokinetic studies showed complete fasted-state absorption of ziprasidone, achieving the desired improvement in the fed/fasted ratio.

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