Effective technology selection for improving bioavailability (BA) can accelerate the development of promising compounds and reduce the overall cost and complexity of drug development. Science-based technology selection requires an understanding of the scientific fundamentals governing drug solubilization, absorption and metabolic fate, as well as the feasibility and performance boundaries between enabling technologies. Capsugel / Bend Research have developed a robust technology selection process facilitated by its breadth of BA-enhancing technologies and extensive experience in advancing hundreds of challenging compounds.