Many drug candidates have low aqueous solubility and, as a result, low bioavailability, often thwarting the progression of otherwise promising active compounds. At Capsugel, we know that innovative, flexible approaches are needed to solve solubility problems, along with an array of technologies to address specific compound characteristics and meet target product profiles. The SDD technology, which was pioneered in Bend, offers a proven, broadly applicable approach to improve bioavailability and enables rapid, reliable advancement of low-solubility compounds. In addition, Capsugel offers a number of other specialized technologies to meet our clients’ needs. We have the formulation, process development, and manufacturing expertise onsite to create custom solutions tailored to our clients’ needs at a variety of scales.
Capsugel’s Center of Excellence for Spray-Dried Dispersion (SDD) Technology at Bend is focused on a breakthrough technology that has been used to advance thousands of compounds with low aqueous solubility. The SDD platform encompasses compositions, processes, and dosage forms designed and proven to meet performance, stability, and manufacturability requirements for a diverse range of compounds. Since it was pioneered in Bend nearly 20 years ago, the SDD platform has proven to be a reliable, highly flexible approach for improving bioavailability, typically from 3- to 15-fold.
Capsugel’s engineering approach is based on fundamental, model-based process development and engineering at all stages of the drug-development process. This focus enables us to address the interaction of formulation physicochemical constraints and process definition to minimize development timelines and risks early in the development process. In late-stage development, these process development models are used to ensure optimization of efficient, robust processes.
Capsugel’s state-of-the-art manufacturing facilities and process expertise in Bend ensure our clients have access to the right technology to meet their needs. Onsite equipment includes spray-drying, extrusion, immediate-and controlled-release tableting, and multiparticulates.
Manufacturing support is phase-specific, so we can prepare formulations at bench scale for early feasibility work in our development laboratories, pilot-scale quantities of supplies in our engineering facility, and clinical and commercial supplies in our current Good Manufacturing Practice (cGMP) manufacturing facility.
Capsugel gives back to the community through a variety of outreach programs. In Bend, we focus on science education due to our unique position in our rural region, but we also support many other organizations that strive to keep Central Oregon a healthier, happier, and safer place to live and work.