Capsugel is a global contract manufacturing and development organization and its Livingston
facility is the world's number one site for liquid and semisolid capsule products. At Livingston, Capsugel offers integrated onsite expertise in all aspects of the product development and manufacture of pharmaceuticals for oral drug delivery. The site’s specialty as a Center of Excellence for liquid-filled hard capsule (LFHC) technology, offers clients an advanced dosage-form solution for liquid, semisolid, paste, and multiparticulate applications, overcoming the formulation challenges associated with other types of liquid-filled capsules. In addition to our product-design and manufacturing experience with LFHC and other drug-delivery systems, Livingston scientists offer a variety of capabilities to clients dealing with problematic compounds.
The Capsugel site in Livingston has more than 25 years of experience in the development and optimization of LFHC technology, making it the world leader and expert in this flexible and elegant dosage form. LFHC technology has a proven record for addressing complex formulation challenges, particularly since the capsules are leak proof and protect the active pharmaceutical ingredient (API) from moisture, oxygen, and light. The capsules can be used with an array of pharmaceutically approved lipid and non-lipid excipients, offering unprecedented formulation flexibility. Because of these characteristics, LFHC dosage forms offer an ideal way to improve or reposition existing formulations.
Capsugel’s Livingston staff has extensive expertise in all aspects of oral drug delivery and provides clients with simple, scalable formulations designed for a successful clinical outcome. Technological solutions are available for immediate- and controlled-release formulations; and combination products.
Particular areas of expertise include the following
As the world’s largest company dedicated to liquid and semi-solid encapsulation, Capsugel understands product development. The company offers a full range of preformulation and formulation development services for new substances or upgrades of existing products. In Livingston, product design expertise includes lipid/solvent/cosolvent formulations, liquid/semi-solid products, targeted colonic-delivery products using LFHC and specialized coatings, dual delivery products with specialized capsule-in-capsule technology, and abuse-deterrent formulations.
Capsugel's experienced team at Livingston has helped hundreds of clients advance their molecules quickly and cost effectively to clinical evaluation, while minimizing the risk of formulation failure.
We provide a full range of Pharmaceutical Development Services from preformulation to prototype formulations for clinical trials, tailoring these to the needs of the client—whether they want a rapid first-in-human development program or a formulation optimized with commercial manufacturing in mind.
Capsugel can support clients for all their clinical trial manufacturing needs (Phase I to IV) and for full commercial-scale manufacturing. This includes high-containment manufacturing for highly potent and cytotoxic products.
Our state-of-the-art facility in the United Kingdom is the largest in the world for the manufacture of liquid and semi-solid filled capsule pharmaceutical products, offering clients unrivalled capacity and flexibility. This facility is approved by the FDA and licensed by the MHRA. The staff at Livingston has built up an unrivalled level of experience and track record in this area, offering