Capsugel’s premier depth in key technologies, breadth of expertise and global infrastructure position us to meet the increasingly complex challenges faced by biopharmaceutical and consumer health and nutrition companies worldwide. At Ploermel, Capsugel utilizes soft gelatin capsule technology, as well as liquid-filled hard capsules (LFHC), to bring a number of formulation and commercial benefits to both pharmaceutical and health & nutrition customers. Softgel technology is a key offering within our bioavailability enhancement suite of technologies, and for specialized product development for low dose, hormones and other challenging applications.
The product development team at Ploermel benefits from the entire network of Capsugel product development sites in Europe and the US, and shares best practices in identifying optimal technologies and approaches for formulation challenges. A full range of pre-formulation and feasibility studies – including lipid-based solubility screening for new chemical entities and in vitro evaluation of lipid-based formulations to predict in vivo behavior – is conducted for client compounds. Dedicated suites are used for small-scale lab encapsulation for feasibility assessments, stability data generation, and final formulation selection.
Liquid and semi-solid fill technology and manufacture are core strengths of Capsugel. These technologies are routinely employed for improved bioavailability, high potency compounds, addressing food effects, improved active ingredient stability, taste and odor masking, as well as effective product differentiation and branding. Our facilities in Ploermel offers the following end-to-end development services: