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Biotherapeutics
To serve market needs created by the biopharmaceutical industry’s increasing investment in biotherapeutic formulations, Capsugel has developed a wide range of science-based problem-solving services to assist biopharmaceutical scientists.
Our offering includes novel formulation and processing solutions for biotherapeutic molecules. We have a wide range of comprehensive tools that improve process understanding and performance, increase target product quality, and reduce operating costs. These services capitalize on major investments in spray-drying facilities — including facilities capable of handling vaccines and molecules that pose moderate potential biosafety hazards — and state-of-the-art cell-culture research facilities featuring recent innovations in process design and process analytical technology (PAT).
Our suite of technologies and services include:
- Protein, Peptide and Vaccine Formulation – rooted in expertise in particle engineering, including spray-drying and solid-state and solution formulation, we provide formulation development services for oral, parenteral, nasal and pulmonary delivery. Capsule technologies are available that enable the oral delivery of acid- and heat-sensitive molecules.
- Streamlined and De-risked Biologics Manufacturing Technologies – our cell culture process development and optimization services are focused on maximizing product quality. The development, optimization and scale-up of biotherapeutic manufacturing processes are performed in a new state-of-the art, dedicated laboratory.
- Modular Automated Sampling Technology (MAST™) – this automated aseptic bioreactor sampling system provides a reliable method for transferring samples directly from bioreactors to analytical devices while maintaining process sterility. The result – improved bioreactor processing efficiency and yields.
Stabilization of HAC1 Influenza Vaccine By Spray Drying
Stable vaccines with long shelf lives and reduced dependency on the cold chain are ideal for stockpiling and rapid deployment during public emergencies, including pandemics. Spray drying is a low-cost process that has potential to produce vaccines stable at a wide range of temperatures.