Best Practices for Spray-Dried Dispersion Formulation Selection and Early Development
Thursday, March 28th, 11am to 12pm (EST)
A large fraction of orally administered small molecules have low aqueous solubility, and, therefore, poor oral absorption. Amorphous dispersions are becoming more widely used as a formulation approach to increasing the oral exposure of such molecules. Spray-dried dispersions (SDD) are one of the most common technologies for producing amorphous dispersions of drug and polymer due to applicability and scalability. There are a number of important considerations that typically need to be addressed early in formulating spray-dried dispersions, including recognition of the rate-limiting step to absorption, (e.g., dissolution rate vs. solubility-permeability limitations), pH-dependent performance, physical and chemical stability issues, and target product profiles.
KEY LEARNING OBJECTIVES:
In this webcast, participants will learn about best practices for SDD formulation development in the areas of manufacturability, performance, and stability. Specific topics will include solvent and polymer selection, formulation optimization using early screening approaches and in-vitro testing, and minimizing development time and formulation screening costs while arriving at technically robust formulation solutions for further development.
Product Development Lead
Lonza Pharma & Biotech