Enabling Formulation of Water-Soluble and Water-Insoluble Molecules using a Lipophilic Salt Approach

September 27, 2016

Pharmaceutical salts have traditionally been used to address formulation issues, including solubility. Preliminary in vitro and in vivo studies indicate that a lipophilic salt selection approach enables lipid formulations by supporting substantially higher loadings—more than 10-fold in some cases—and increased solubilization in the GI tract than otherwise possible using free API. The use of lipophilic salt forms can give more APIs access to the well-established benefits of lipid formulations by overcoming certain product design constraints, such as the number and/or size of dosage unit.

This webcast will describe an approach to prepare lipophilic salt forms for a range of APIs and formulate these in concentrated lipid formulations ready for oral delivery. 

Key Learning Objectives:

  • Recognize the basic properties of lipophilic salt forms of API and potential innovative applications in drug delivery
  • Understand how lipophilic salt forms increase API solubility in lipid vehicles and enable the development of highly concentrated lipid formulations (supported by hydrophilic and hydrophobic API case studies)
  • Explore biopharmaceutical synergies between the lipophilic salt form and lipid formulations for increased API solubilization and absorption

Presented by:

  • Dr. Hywel Williams, Principal Scientist, Capsugel

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