Pharmaceutical salts have traditionally been used to address formulation issues, including solubility. Preliminary in vitro and in vivo studies indicate that a lipophilic salt selection approach enables lipid formulations by supporting substantially higher loadings—more than 10-fold in some cases—and increased solubilization in the GI tract than otherwise possible using free API. The use of lipophilic salt forms can give more APIs access to the well-established benefits of lipid formulations by overcoming certain product design constraints, such as the number and/or size of dosage unit.
This webcast will describe an approach to prepare lipophilic salt forms for a range of APIs and formulate these in concentrated lipid formulations ready for oral delivery.
Key Learning Objectives: