Engineering the Mechanical Properties of Amorphous Spray-Dried Dispersions

February 23, 2016

Drug candidates with low oral absorption potential in the crystalline state are frequently converted to the amorphous form to increase solubility, prevent precipitation, and increase dissolution rate, thereby improving the extent of absorption and bioavailability. Spray drying drug from a solution containing an amphiphilic polymer is one of the most common and scalable methods used to achieve these enabling properties. The resulting powder contains the amorphous drug molecularly suspended or solubilized within the polymer matrix. Typical crystalline drug properties, often unfavorable for downstream processing, are masked by the amorphous state of the drug and matrix polymer. 

In this webinar, experts will discuss:

  • How particle engineering by spray drying can be used to co-optimize several facets of SDD development with a specific focus on optimization of SDD mechanical properties
  • Reduction of SDD tableting scale up risks and pill burden through identification of the primary mechanism of compaction and rational formulation design
  • Development case studies highlighting SDDs whose primary mechanism of compaction is plastic flow versus brittle fracture

Presented by:

  • Aaron Goodwin, Ph.D., Principal Investigator Research and Development, Bend Research
  • Randy Wald, Senior Research Fellow, Bend Research
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