Drug candidates with low oral absorption potential in the crystalline state are frequently converted to the amorphous form to increase solubility, prevent precipitation, and increase dissolution rate, thereby improving the extent of absorption and bioavailability. Spray drying drug from a solution containing an amphiphilic polymer is one of the most common and scalable methods used to achieve these enabling properties. The resulting powder contains the amorphous drug molecularly suspended or solubilized within the polymer matrix. Typical crystalline drug properties, often unfavorable for downstream processing, are masked by the amorphous state of the drug and matrix polymer.
In this webinar, experts will discuss: