Hydroxypropyl methylcellulose (HPMC) capsules are well-vetted and have been used in pharmaceutical formulations for many years. But a new HPMC-polymer capsule (Vcaps® Plus) made through an innovative thermo-gelation process avoids the addition of gelling agents that can react with the pH or ionic strengths of dissolution media, providing gelatin-like performance.
Although HPMC capsules are used in marketed drugs, there are few comparisons of the in-vivo performance between gelatin and HPMC in literature.
Key Learning Objectives:
Matt Richardson, Ph.D., Manager, Pharmaceutical Business Development, Capsugel
Michael Morgen, Ph.D., Senior Principal Scientist, Bend Research