Webinar - Utilizing Spray-Dried Dispersion Technology for Bioavailability Enhancement: Overview and Case Studies

November 15, 2018

Utilizing Spray-Dried Dispersion Technology for Bioavailability Enhancement: Overview and Case Studies

Thursday, November 15, 2018, 11:00 AM EST/8:00 AM PST

A large fraction of orally administered small molecules have poor oral absorption due to low aqueous solubility or dissolution rate. Amorphous dispersions are becoming more widely used as a formulation approach to increase the oral exposure of such molecules. Spray-dried dispersions (SDD) is increasingly the preferred technology for producing amorphous dispersions of drug and polymer due to applicability and scalability across a diverse compound space. Selecting the optimal SDD composition for maximizing performance, maintaining physical and chemical stability, and achieving the target product profile in vivo requires that key parameters be tailored to the specific drug and balanced relative to additional factors such as manufacturability and cost.

In this webcast, participants will learn about best practices for SDD formulation development with an emphasis on SDD scale-up, manufacture, and subsequent bio-performance.

Presented by:

  • Aaron Stewart, Senior Scientist
  • Alyssa Ekdahl ,Engineer


 


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