Performance Qualification of a New Hypromellose Capsule Part II

International Journal of PharmaceuticsPart II Disintegration and Dissolution Comparison Between Two Types of Hypromellose CapsulesThis paper describes the disintegration and dissolution aspects of the qualification of a new hypromellose capsule (HPMC Shell 2). This new capsule does not contain any gelling agent, and is manufactured by a thermal gelation process. Rupture time of the carrageenan-containing capsule (HPMC Shell 1) and HPMC Shell 2, as measured by an improved real-time detection method, showed only slight differences that did not manifest in vivo.

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