A Better Way to Deliver Microbiome-Based Therapies

Ready-to-fill enteric capsules designed for targeted intestinal release

A Unique Platform for Enteric Delivery

Capsugel® Enprotect® capsule is a ready-to-fill enteric capsule designed to protect sensitive payloads from gastric conditions and enable targeted intestinal release, without the need for post-fill coating. Its proprietary bi-layer capsule technology combines acid protection with simplified development and manufacturing.

Key Features & Benefits

Targeted intestinal release
Protection of sensitive APIs up to pH 6.0
No post-fill coating required
Ready-to-fill technology
Customizable and scalable technology
Compatible with powder and liquid formulations

Request a Capsugel® Enprotect® Sample Bottle

Sample requests are subject to review and approval by Capsugel. Submission of a request does not guarantee sample availability or fulfillment.

Why Capsugel® Enprotect® capsules for Microbiome-Based Therapies?

Microbiome-based therapies often require protection from gastric conditions while ensuring localized delivery in the intestinal tract. Capsugel® Enprotect® capsule provides targeted intestinal delivery in a ready-to-fill enteric capsule format.

Markets & Applications: Pharma & Biopharma
• Potential applications include:
• Live Biotherapeutic Products (LBPs)
• Fecal Microbiota Transplantation (FMT)
• Microbiome-modulating therapies
• Intestinally targeted biologics
• Peptides and proteins requiring gastric protection
• Other locally acting intestinal therapies

Learn more about Capsugel® Enprotect® capsule: Enprotect® Enteric | Capsugel

Fecal Microbiota Transplantation (FMT) has emerged as an important therapeutic approach for restoring a disrupted intestinal microbiota, particularly in recurrent Clostridioides difficile infection. As the field evolves, oral capsule delivery is increasingly being adopted as a patient-friendly alternative to invasive administration routes.

Published studies have demonstrated the use of Capsugel® Enprotect® capsules for oral FMT applications^1,2, including preservation of microbiota integrity during processing and storage and retention of enteric performance after storage at -80°C³.

Learn more: Enhancing FMT Delivery: Exploring the Use of Capsugel® Enprotect® Capsules | Capsugel1.

Hansen MM, et al. Therap Adv Gastroenterol. 2024 Oct 13;17:17562848241289065. doi: 10.1177/17562848241289065. PMID: 39421003; PMCID: PMC11483698.
Augustijn QJJ, et al. BMJ Open 2025;15:e088290. doi:10.1136/bmjopen-2024-088290 1
Poster: Enprotect-Fecal-Microbiota-Transplant-poster | Capsugel

Download the Product Specification Brochure for detailed information on: