Protection of probiotics filled in non-coated Capsugel® DRcaps™ acid-resistant hypromellose capsules

The aim of the study was to compared the use of gelatin and DRcaps™ acid resistant Hypromellose hard capsules for the intestinal delivery of probiotics. Whereas classical gelatin capsules disintegrated under the simulated stomach conditions, DRcaps™ capsules with their gastric acid resistance allowed to overcome the stomach conditions.