Over the last twenty years, we have built an unrivaled level of experience and track record in designing and developing LFHC formulations, as well as the liquid filling of hard-shell capsules. Our specialized liquid filling and sealing equipment enables our liquid filled and semi-solid fill technology, one of our core strengths.
Lonza’s focus on science & engineering has led to the development of proprietary equipment and processing techniques, to provide optimal efficiency, reliability and productivity for our LFHC clients.
Two sealing technology options are available to pharmaceutical and biotech companies developing liquid-filled hard capsule products. Capsule banding, where a visible band of gelatin or HPMC is applied around the joint between the capsule – thus sealing the caps to the body of the capsule – is one approach. The second option is Lonza’s proprietary LEMS® (Liquid Encapsulation Micro Spray) or “Fusion” technology, which utilizes the application of a fine micro-spray of sealing solution around the joint between the body and the cap of the capsule so that the contacting surfaces of the cap and the body are effectively fused together.
Our engineering advancements in capsule filling and sealing of liquid hard-shell capsules – spanning more than 25 years – helps achieve consistent product quality and a robust, leak-proof seal using either of these sealing technologies.
Take advantage of the Licaps® liquid-filled hard capsules (LFHC) to help formulate new compounds with improved functionality while providing an elegant and differentiated product presentation. LFHC and lipid-based technology is routinely used for several functional improvements including bioavailability enhancement, taste and odor masking and combination products.