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This article, originally published in Originale pharmind in 2009, explores the bioavailability challenges in drug delivery. SEDDS are pre-concentrates of excipients with a drug substance that form a thermodynamically stable micro-emulsion upon contact with aqueous media. The drug substance is kept in a solubilized form, thus improving the pharmacokinetic profile of BCS Class 2 drug substances and to optimize efficacy and safety.
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