AAPS 2015 Poster - Modified Release - W4158 - Prolonged Gastric Acid Resistance Using a New Double Hypromellose Capsule Approach

DRcaps®, HPMC based capsules developed by Capsugel, are well accepted non-animal acid resistant two piece hard capsules. Extending the time post-dosing at which drug is released from a capsule can potentially help site-specific drug delivery. The aim of this study was to evaluate the benefit of DRcaps® capsule acid resistance in a double capsule concept and extend the period of delayed release.

DRcaps acid resistance is not affected by the presence of up to 40% alcohol in the dissolution media
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