Amorphous dispersions prepared by spray-drying or hot melt extrusion (HME) can increase the oral bioavailability of a wide range of drugs by enabling supersaturation in the upper intestine and sustaining that supersaturation long enough to increase the driving force for permeability. Recent work on amorphous dissolution has demonstrated the ability to readily detect amorphous phase separation in aqueous solutions. This poster describes development of a rapid assay for determining amorphous solubility and data that demonstrate that polymers and surfactants can prevent drug crystallization from the supersaturated state in biorelevant media.