AAPS 2015 Poster - Bioavailability Enhancement - R6106 - A Rapid Screening Tool for Assessing the Utility of Amorphous Dispersions for Bioavailability Enhancement

Amorphous dispersions prepared by spray drying or hot melt extrusion can increase oral bioavailability of a wide range of drugs by leading to supersaturation in the upper intestine and sustaining that supersaturation long enough to increase the driving force for permeability. Recent work on amorphous dissolution has demonstrated the ability to readily detect amorphous phase separation in aqueous solutions. Based on this work, we set out to develop a rapid assay for determining amorphous solubility and the ability of polymers and surfactants to prevent crystallization from the supersaturated state in biorelevant media.

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