AAPS 2015 Poster - Bioavailability Enhancement - W5055 - Formulation design and evaluation of self-emulsifying drug delivery systems (SEDDS) for a poorly water-soluble BCS II Compound

Robust SEDDS formulation development is based on in-depth analysis and understanding of a given API’s physicochemical and biological characteristics and, if appropriate, the consequent selection of specific lipid- based excipients known to have physiological effects. The purpose of this study was to leverage internal know-how and methodologies to develop lipid formulations that address solubility and metabolic barriers to the oral bioavailability of a BCS class II API.

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