Development of robust self-emulsifying drug delivery system (SEDDS) formulations must be grounded in in-depth analysis and understanding of the drug’s physicochemical and biological characteristics. Based on these characteristics, selection of lipid-based excipients with specific physiological effects may be required. This poster describes work to leverage know-how and methodologies to develop lipid formulations that address solubility and metabolic barriers to the oral bioavailability of a low-solubility compound.