How can powder fill weight be controlled?

The filling of the DPI capsule is done by automated equipment with a very accurate scale. As a typical inhalation formula is less than 40mg of powder, it is critical to obtain consistency in capsule weight to avoid variations in active drugs doses. Depending on the polymer, the weight variation is usually around 4% of the capsule weight, which meets most customer requirements. Based on specific dosage or customer needs, this variation level can be reduced to 1%.