Hot-Melt Extrusion Fundamentals: Processing of Amorphous Solid Dispersions for Poorly Soluble Drugs

In this webinar, scientists from Bend Research will provide insight into HME fundamentals, including solid dispersion formulation selection. Strategies and case studies for solid dispersion formulation selection and definition of a HME process operating space will be reviewed.

An estimated 60 percent of compounds in early development have poor solubility due to low solubility and dissolution rates (DCS IIa and IIb). Hot-melt extrusion (HME) of amorphous solid dispersions is one approach Bend Research, a division of Capsugel Dosage Form Solutions, uses to address APIs with limited bioavailability. By using small scale screening techniques and an integrated process and formulation approach, Bend Research is able to rapidly develop a progressable drug intermediate and dosage form for preclinical and clinical manufacture. These approaches balance the target absorption profile, manufacturability, physical and chemical stability, and API availability.

Presented By:

• Charlie McLaughlin, Engineering Technical Group Lead
• Scott Bone, Chemistry Technical Group Lead