Protein, Peptide, & Vaccine Formulations

Optimizing existing formulations, developing new formulations, and understanding delivery modalities requires stable and scalable biotherapeutic formulations.

Capsugel strives to understand the stability and scalability challenges associated with biotherapeutics and develop solutions. We use solid-state formulations as a solution for shipping intermediate or final drug products, as well as mitigating cold chain storage and applications in developing nations. The formulations we develop are suitable for clinical and commercial production in existing current Good Manufacturing Practice (cGMP) facilities.

Our offering is focused on the following areas:

  • Formulation development using spray drying, pioneered by Bend Research, including at large scales (development and cGMP) and in high containment facilities, with a focus on spray-drying and capsule-based delivery solutions
  • Biologic, chemical, and physical characterization of biotherapeutics, including antibodies and vaccines
  • Dosage form development based on particle engineering for oral, parenteral, nasal, and pulmonary delivery
  • Intrinsically enteric capsule technology for oral delivery and rapid pre-clinical development
  • Scale-up and technology transfer based on fundamental scientific and engineering understanding
Interested in learning more about Protein, Peptide, & Vaccine Formulations?
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Simple Steps to Help R&D Speed to Market
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Formulation of Biologics for Inhalation Drug Delivery
Join Capsugel Dosage Form Solutions and the Lovelace Respiratory Research Institute for a webinar organized by the AAPS Inhalation Technology Focus Group. Learn more!
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Using Engineered Particles in Capsules for Rapid-to-Clinic Dry Powder Inhalation Applications
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Stabilization of HAC1 Influenza Vaccine by Spray Drying: Formulation Development and Process Scale-Up

Stable vaccines with long shelf lives and reduced dependency on the cold chain are ideal for stockpiling and rapid deployment during public emergencies, including pandemics. Spray drying is a low-cost process that has potential to produce vaccines stable at a wide range of temperatures. 

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